Dietary supplement is defined as any product taken orally containing a “dietary ingredient” (vitamins, minerals, herbs, amino acids, enzymes, etc.) that is intended to supplement one’s diet. They include plant extracts and food concentrates. Their main purpose is to provide the required nutrients and to fulfill the daily nutritional needs. Sports professionals should be aware of the possible benefits of the supplements as well as the side effects and associated risks towards taking advantage of the supplements for daily training and competitive performance. This article provides a comprehensive overview of dietary supplements mainly related to athletes’ health and performance. In addition we discuss recent studies related to the attitudes of professionals in Saudi Arabia toward dietary supplements and how to aid them in making more informed decisions and judicial choices of dietary supplements for gaining health benefits.